列表页top

您现在的位置:新闻首页>综合资讯

Results from RE-SPECT CVT

2019-09-04 17:10第三视角网编辑:admin人气:


  • Study published in JAMA Neurology investigated      Pradaxa® (dabigatran etexilate) in patients with cerebral      venous and dural sinus thrombosis (CVT)

  • First exploratory study of a non-vitamin K      antagonist oral anticoagulant (NOAC) in this population

  • The study is part of Boehringer Ingelheim’s      commitment to advancing thrombosis care

INGELHEIM, Germany -- (BUSINESS WIRE) --

Boehringer Ingelheim today announced the publication of primary analysis from RE-SPECT CVT®, the first exploratory, prospective, randomised controlled study of a NOAC in patients with blood clots in the veins or venous sinuses of the brain. The trial investigated the safety and efficacy of Pradaxa® (dabigatran etexilate) and dose-adjusted warfarin in patients with CVT.

The results provide insight into the role of anticoagulation in patients with CVT of mild-moderate severity. In the study, there were no recurrent venous thromboembolism (VTE) events in either treatment group. The trial also found that the rate of bleeding was low, with two patients in the warfarin arm (3.3%) and one (1.7%) in the dabigatran arm developing a major bleed. There was no mortality in either treatment arm in this study.1

“Cerebral venous thrombosis, CVT, which affects predominantly young patients and women, can cause death and disability. Patients who survive the acute phase of CVT may suffer recurrent venous thrombosis. To prevent that, the usual clinical practice is to prescribe vitamin K antagonists (VKAs, such as warfarin). VKAs present limitations in terms of safety, dosing, reversibility and patient preference,” said Professor José M. Ferro, Director of the Department of Neurosciences and Mental Health at the Hospital Santa Maria in Lisbon, Portugal, and Chair of the RE-SPECT CVT Steering Committee. “RE-SPECT CVT was the largest trial performed in patients with CVT to date, enrolling 120 patients. The trial showed that the risk of recurrent VTE in CVT patients of mild to moderate severity under anticoagulant therapy with dabigatran for six months was low and associated with few major or clinically relevant bleeding events.”

The trial forms part of Boehringer Ingelheim’s ongoing commitment to expanding scientific knowledge of thrombosis care. Additionally, it furthers the understanding of the safety profile of dabigatran, which has been documented in the extensive RE-VOLUTION® trial and registry programme.2-24

About the RE-SPECT CVT® study
Randomised evaluation of the safety and efficacy of dabigatran etexilate versus dose adjusted warfarin in patients with cerebral venous thrombosis (RE-SPECT CVT®)1
RE-SPECT CVT® was a prospective, randomised exploratory study assessing the safety and efficacy of dabigatran etexilate and warfarin in patients who suffer from CVT. The open-label study involved 120 patients from nine countries and looked to evaluate the suitability of dabigatran etexilate and warfarin for the treatment and secondary prevention of blood clots in the veins or venous sinuses of the brain. Patients aged ≥ 18 years old with a confirmed diagnosis of CVT (with or without haemorrhagic stroke) were randomised to receive either warfarin or dabigatran etexilate.1

Please click on the following link for ‘Notes to Editors’ and ‘References’: http://www.boehringer-ingelheim.com/press-release/re-spect-cvt-study-data-published

Intended audiences:
This press release is issued from our Corporate Headquarters in Ingelheim, Germany and is intended to provide information about our global business. It is directed to the international audience outside Germany. Please be aware that information relating to the approval status and labels of approved products may vary from country to country, and a country-specific press release on this topic may have been issued in the countries where we do business.


(来源:国际文传电讯社)

已推荐
0
  • 凡本网注明"来源:第三视角网的所有作品,版权均属于中第三视角网,转载请必须注明中第三视角网,http://www.dsshijiao.com。违反者本网将追究相关法律责任。
  • 本网转载并注明自其它来源的作品,目的在于传递更多信息,并不代表本网赞同其观点或证实其内容的真实性,不承担此类作品侵权行为的直接责任及连带责任。其他媒体、网站或个人从本网转载时,必须保留本网注明的作品来源,并自负版权等法律责任。
  • 如涉及作品内容、版权等问题,请在作品发表之日起一周内与本网联系,否则视为放弃相关权利。





图说新闻

更多>>
焕多多——让生意活起来

焕多多——让生意活起来